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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1418| Simple approach for ranking structure determining residues | |
| OSCAR DANIEL LUNA MARTINEZ ABRAHAM MARCELINO VIDAL LIMON MIRYAM IVETTE VILLALBA VELAZQUEZ RAMON GARDUÑO JUAREZ Vladimir Uversky BALTAZAR BECERRIL LUJAN | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.7717/peerj.2136 | |
| Molecular dynamics Shannon dynamical entropy Intrinsic disorder Thermodynamics | |
| "Mutating residues has been a common task in order to study structural properties of the protein of interest. Here, we propose and validate a simple method that allows the identification of structural determinants; i.e., residues essential for preservation of the stability of global structure, regardless of the protein topology. This method evaluates all of the residues in a 3D structure of a given globular protein by ranking them according to their connectivity and movement restrictions without topology constraints. Our results matched up with sequence-based predictors that look up for intrinsically disordered segments, suggesting that protein disorder can also be described with the proposed methodology." | |
| PeerJ, Inc | |
| 2016-06 | |
| Artículo | |
| Luna-Martínez OD, Vidal-Limón A, Villalba-Velázquez MI, Sánchez-Alcalá R, Garduño-Juárez R, Uversky VN, Becerril B. (2016) Simple approach for ranking structure determining residues. PeerJ 4:e2136 https://doi.org/10.7717/peerj.2136 | |
| BIOLOGÍA MOLECULAR | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| PeerJ4(2016)e2136.pdf | 11.98 MB | Adobe PDF | Visualizar/Abrir |