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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1440| 2D-DIGE as a strategy to identify serum biomarkers in Mexican patients with Type-2 diabetes with different body mass index | |
| Erik Elvin Gómez Cardona Eric Edmundo Hernández Domínguez AIDA JIMENA VELARDE SALCEDO Alberto Barrera Pacheco Agustín Diaz Gois Antonio de León Rodríguez Ana Paulina Barba de la Rosa | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1038/srep46536 | |
| Predictive markers Protein–protein interaction networks | |
| "Obesity and type 2 diabetes (T2D) are the most prevalent and serious metabolic diseases affecting people worldwide. However racial and ethnic disparities seems to be a risk factor for their development. Mexico has been named as one of the largest populations with the highest prevalence of diabetes and obesity. The aim of this study was to identify novel T2D-associated proteins in Mexican patients. Blood samples were collected from 62 Mexican patients with T2D and they were grouped according to their body mass index (BMI). A panel of 10 diabetes and obesity serum markers was determined using MAGPIX. A comparative proteomics study was performed using two-dimensional difference in-gel electrophoresis (2D-DIGE) followed by mass spectrometry (LC-MS/MS). We detected 113 spots differentially accumulated, in which 64 unique proteins were identified, proteins that were involved in metabolism pathways, molecular transport, and cellular signalling. Four proteins (14-3-3, ApoH, ZAG, and OTO3) showing diabetes-related variation and also changes in relation to obesity were selected for further validation by western blotting. Our results reveal new diabetes related proteins present in the Mexican population. These could provide additional insight into the understanding of diabetes development in Mexican population and may also be useful candidate biomarkers." | |
| Nature Publishing Group | |
| 2017-04 | |
| Artículo | |
| Gómez-Cardona, E. E., Hernández-Domínguez, E. E., Velarde-Salcedo, A. J., Pacheco, A.-B.-, Diaz-Gois, A., De León-Rodríguez, A., & Barba de la Rosa, A. P. (2017). 2D-DIGE as a strategy to identify serum biomarkers in Mexican patients with Type-2 diabetes with different body mass index. Scientific Reports, 7, 46536. http://doi.org/10.1038/srep46536 | |
| CIENCIAS TECNOLÓGICAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| ScientificReports7(2017)46536.pdf | 1.08 MB | Adobe PDF | Visualizar/Abrir |