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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1481| Identification of differential expressed transcripts in cervical cancer of Mexican patients | |
| MARTHA LETICIA SANTOS MARTINEZ Ma. Fabiola León Galván ERIKA NAHOMY MARINO MARMOLEJO Ana Paulina Barba de la Rosa Antonio de León Rodríguez Roberto Fidencio González Amaro Ramón Gerardo Guevara González | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1007/s13277-010-0151-4 | |
| Cervical cancer SSH Gene expression Mexican women | |
| "The aim of this study was to identify the gene expression profile in biopsies of patients with cervical intraepithelial neoplasia (CIN) 1, CIN 2, CIN 3, and microinvasive cancer by suppression subtractive hybridization and Southern blotting. After analyzing 1,800 cDNA clones, we found 198 upregulated genes, 166 downregulated, and no significant change of gene expression in 86 clones (p = 0.005). These results were validated by Northern blot analysis (p = 0.0001) in the identification of 28 overexpressed and 7 downregulated transcripts. We observed a set of genes related to the Notch signaling pathway that may be involved in the transformation of cervical cells and in the development to malignancy. The differentially expressed genes may provide useful information about the molecular mechanisms involved in human cervical carcinoma and as diagnostic markers." | |
| Springer | |
| 2011-06 | |
| Artículo | |
| Santos, L., León-Galván, M.F., Marino-Marmolejo, E.N. et al. Tumor Biol. (2011) 32: 561. https://doi.org/10.1007/s13277-010-0151-4 DOI | |
| ONCOLOGÍA | |
| Versión aceptada | |
| acceptedVersion - Versión aceptada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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