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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1932| Thermoplasma acidophilum TAA43 is an archaeal member of the eukaryotic meiotic branch of AAA ATPases | |
| MARTHA LETICIA SANTOS MARTINEZ Tancred Frickey Jürgen Peters Wolfgang Baumeister Andrei N. Lupas Peter Zwickl | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1515/BC.2004.144 | |
| Archaea Proteasome activating nucleotidase Proteasome VAT VAT2 | |
| "Sequencing of the Thermoplasma acidophilum genome revealed a new gene, taa43, which codes for a 43-kDa protein containing one AAA domain; we therefore termed it Thermoplasma AAA ATPase of 43 kDa (TAA43). Close homologs of TAA43 are found only in related Thermoplasmales, e.g. T. volcanium and Ferroplasma acidarmanus, but not in other Archaea. A detailed phylogenetic analysis showed that TAA43 and its homologs belong to the ‘meiotic’ branch of the AAA family. Although AAA proteins usually assemble into high-molecular-weight complexes, native TAA43 is predominantly dimeric except for a minor fraction eluting in the void volume of a sizing column. Wild-type and mutant TAA43 proteins were overexpressed in Escherichia coli, purified as dimers and characterized functionally. Since the canonical proteasome activating nucleotidase is not present in Thermoplasmales, TAA43 was tested for stimulation of proteasome activity, which was, however, not detected. Interestingly, immunoprecipitation analysis with TAA43 specific antibodies found a fraction of native TAA43 associated with Thermoplasma ribosomal proteins." | |
| Walter de Gruyter GmbH | |
| 2005 | |
| Artículo | |
| Santos, L., Frickey, T., Peters, J., et al. (2005). Thermoplasma acidophilum TAA43 is an archaeal member of the eukaryotic meiotic branch of AAA ATPases. Biological Chemistry, 385(11), pp. 1105-1111. Retrieved 27 Mar. 2019, from doi:10.1515/BC.2004.144 | |
| BIOLOGÍA MOLECULAR | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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