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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1966| Timbe (Acaciella angustissima) pods extracts reduce the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in streptozotocin-induced diabetic rats | |
| ADRIANA JHENY RODRIGUEZ MENDEZ WENDY MONSERRAT CARMEN SANDOVAL MARIA DEL CONSUELO LOMAS SORIA Ramón Gerardo Guevara González ROSALIA REYNOSO CAMACHO MA. ELENA VILLAGRAN HERRERA Luis Antonio Salazar Olivo Irineo Torres Pacheco ANA ANGELICA FEREGRINO PEREZ | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/molecules23112812 | |
| Acacciella angustissima Streptozotocin-diabetic rats Antidiabetic effect Polyphenolic Protocatechuic acid | |
| "In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of ?-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats." | |
| MDPI AG | |
| 2018 | |
| Artículo | |
| Rodríguez-Méndez, A.J.; Carmen-Sandoval, W.; Lomas-Soria, C.; Guevara-González, R.G.; Reynoso-Camacho, R.; Villagran-Herrera, M.E.; Salazar-Olivo, L.; Torres-Pacheco, I.; Feregrino-Pérez, A.A. Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats. Molecules 2018, 23, 2812. | |
| BIOLOGÍA MOLECULAR | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| Molecules23(2018)2812.pdf | 1.09 MB | Adobe PDF | Visualizar/Abrir |