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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1125| Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata | |
| MAYRA CUELLAR CRUZ IRENE BEATRIZ CASTAÑO NAVARRO OMAR ELIND ARROYO HELGUERA ALEJANDRO DE LAS PEÑAS NAVA | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| http://dx.doi.org/10.1590/S0074-02762009000400020 | |
| "Candida glabrata is an opportunistic fungal pathogen that can cause severe invasive infections and can evade phagocytic cell clearance. We are interested in understanding the virulence of this fungal pathogen, in particular its oxidative stress response. Here we investigated C. glabrata, Saccharomyces cerevisiae and Candida albicans responses to two different oxidants: menadione and cumene hydroperoxide (CHP). In log-phase, in the presence of menadione, C. glabrata requires Cta1p (catalase), while in a stationary phase (SP), Cta1p is dispensable. In addition, C. glabrata is less resistant to menadione than C. albicans in SP. The S. cerevisiae laboratory reference strain is less resistant to menadione than C. glabrata and C. albicans; however S. cerevisiaeclinical isolates (CIs) are more resistant than the lab reference strain. Furthermore, S. cerevisiae CIs showed an increased catalase activity. Interestingly, in SP C. glabrata and S. cerevisiae are more resistant to CHP than C. albicans and Cta1p plays no apparent role in detoxifying this oxidant." | |
| Instituto Oswaldo Cruz | |
| 2009-07 | |
| Artículo | |
| Inglés | |
| Público en general | |
| Cuéllar-Cruz, Mayra, Castaño, Irene, Arroyo-Helguera, Omar, & De Las Peñas, Alejandro. (2009). Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata. Memórias do Instituto Oswaldo Cruz, 104(4), 649-654 | |
| BIOLOGÍA Y QUÍMICA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| MemInstOswaldoCruz104(2009)649.pdf | 884.54 kB | Adobe PDF | Visualizar/Abrir |