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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1249| Genetic diversity of the Mycobacterium tuberculosis Complex in San Luis Potosí, México | |
| MA. ESTELA LOPEZ ROCHA JULIO ALFREDO JUAREZ ALVAREZ LINA RAQUEL RIEGO RUIZ JOSE ANTONIO ENCISO MORENO RUBEN HIPOLITO LOPEZ REVILLA | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1186/1756-0500-6-172 | |
| Tuberculosis Mycobacterium bovis Spoligotypes Molecular epidemiology San Luis Potosí Mexico Social determinants of tuberculosis | |
| "Background Although epidemiologic and socioeconomic criteria and biomedical risk factors indicate high-priority for tuberculosis (TB) control in Mexico, molecular epidemiology studies of the disease in the country are scarce. Methods Complete sociodemographic and clinical data were obtained from 248 of the 432 pulmonary TB (PTB) cases confirmed from 2006 to 2010 on the population under epidemiological surveillance in the state of San Luis Potosí, México. From most PTB cases with complete data Mycobacterium tuberculosis complex (MTC) isolates were recovered and their spoligotypes, lineages and families, geographic distribution and drug resistance determined. Results Pulmonary tuberculosis incidence ranged from 2.4 to 33.4 (cases per 100,000 inhabitants) in the six state sanitary jurisdictions that were grouped in regions of low (jurisdictions I-II-III), intermediate (jurisdictions IV-V) and high incidence (jurisdiction VI) with 6.2, 17.3 and 33.4 rates, respectively. Most patients were poor, 50-years-median-age males and housewives. Among the 237 MTC spoligotyped isolates, 232 corresponded to M. tuberculosis (104 spoligotypes in 24 clusters) and five to M. bovis. The predominant Euro-American lineage was distributed all over the state, the East-Asian lineage (Beijing family) in the capital city, the Indo-Oceanic (Manila family) in eastern localities, and M. bovis in rural localities. Conclusions In San Luis Potosí TB affects mainly poor male adults and is caused by M. tuberculosis and to a minor extent by M. bovis. There is great genotypic diversity among M. tuberculosis strains, the Euro-American lineage being much more prevalent than the Indo-Oceanic and East-Asian lineages. The frequency of resistant strains is relatively low and not associated to any particular lineage." | |
| BioMed Central Ltd | |
| 2013 | |
| Artículo | |
| Inglés | |
| Público en general | |
| López-Rocha et al.: Genetic diversity of the Mycobacterium tuberculosis Complex in San Luis Potosí, México. BMC Research Notes 2013 6:172. doi:10.1186/1756-0500-6-172 | |
| BIOLOGÍA Y QUÍMICA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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