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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1276| The corn smut (‘Huitlacoche’) as a new latform for oral vaccines | |
| MARGARITA JUAREZ MONTIEL ANDREA ROMERO MALDONADO ELIZABETH MONREAL ESCALANTE SERGIO ROSALES MENDOZA JUAN FRANCISCO JIMENEZ BREMONT | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1371/journal.pone.0133535 | |
| "The development of new alternative platforms for subunit vaccine production is a priority in the biomedical field. In this study, Ustilago maydis, the causal agent of common corn smut or 'huitlacoche' has been genetically engineered to assess expression and immunogenicity of the B subunit of the cholera toxin (CTB), a relevant immunomodulatory agent in vaccinology. An oligomeric CTB recombinant protein was expressed in corn smut galls at levels of up to 1.3 mg g(-1) dry weight (0.8% of the total soluble protein). Mice orally immunized with 'huitlacoche'-derived CTB showed significant humoral responses that were well-correlated with protection against challenge with the cholera toxin (CT). These findings demonstrate the feasibility of using edible corn smut as a safe, effective, and low-cost platform for production and delivery of a subunit oral vaccine. The implications of this platform in the area of molecular pharming are discussed." | |
| Public Library of Science | |
| 2015-07 | |
| Artículo | |
| Inglés | |
| Público en general | |
| Juárez-Montiel M, Romero-Maldonado A, Monreal-Escalante E, Becerra-Flora A, Korban SS, Rosales-Mendoza S, et al. (2015) The Corn Smut (‘Huitlacoche’) as a New Platform for Oral Vaccines. PLoS ONE 10(7): e0133535. https://doi.org/10.1371/journal.pone.0133535 | |
| OTRAS ESPECIALIDADES TECNOLÓGICAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| PLoSONE10(2015)e0133535.PDF | 2.03 MB | Adobe PDF | Visualizar/Abrir |