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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1439| Directing the self-assembly of tumour spheroids by bioprinting cellular heterogeneous models within alginate/gelatin hydrogels | |
| Tao Jiang José Gil Munguía López SALVADOR FLORES TORRES Joel Grant Sanahan Vijayakumar Antonio de León Rodríguez Joseph Kinsella | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1038/s41598-017-04691-9 | |
| Biomaterials – cells Biomedical engineering Cancer models Tissue engineering | |
| "Human tumour progression is a dynamic process involving diverse biological and biochemical events such as genetic mutation and selection in addition to physical, chemical, and mechanical events occurring between cells and the tumour microenvironment. Using 3D bioprinting we have developed a method to embed MDA-MB-231 triple negative breast cancer cells, and IMR-90 fibroblast cells, within a cross-linked alginate/gelatin matrix at specific initial locations relative to each other. After 7 days of co-culture the MDA-MB-231 cells begin to form multicellular tumour spheroids (MCTS) that increase in size and frequency over time. After similar to 15 days the IMR-90 stromal fibroblast cells migrate through a non-cellularized region of the hydrogel matrix and infiltrate the MDA-MB-231 spheroids creating mixed MDA-MB-231/IMR-90 MCTS. This study provides a proof-of-concept that biomimetic in vitro tissue coculture models bioprinted with both breast cancer cells and fibroblasts will result in MCTS that can be maintained for durations of several weeks." | |
| Nature Publishing Group | |
| 2017-07 | |
| Artículo | |
| Jiang, T., Munguia-Lopez, J.G., Flores-Torres, S. et al. Directing the Self-assembly of Tumour Spheroids by Bioprinting Cellular Heterogeneous Models within Alginate/Gelatin Hydrogels. Sci Rep 7, 4575 (2017). https://doi.org/10.1038/s41598-017-04691-9 | |
| CIENCIAS TECNOLÓGICAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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|---|---|---|---|
| ScientificReports7(2017)4575.pdf | 3.87 MB | Adobe PDF | Visualizar/Abrir |