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Expansion of human hematopoietic stem cells for transplantation: trends and perspectives
Hera Andrade Zaldívar
MARTHA LETICIA SANTOS MARTINEZ
Antonio de León Rodríguez
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.1007/s10616-008-9144-1
2D-culture
3D-culture
Human cells
Leukemia
Rotating wall vessel
Stirred tank
Transplant
"Umbilical cord blood transplantation is clinically limited by its low progenitor cell content. Ex vivo expansion has become an alternative to increase the cell dose available for transplants. Expansion has been evaluated in several ways such as static cultures combining growth factors or mimicking the natural microenvironment using co-culture systems. However, static cultures have a small volume capacity and therefore large-scale expansion has been addressed using bioreactors. These and other biotechnological approaches for the expansion of hematopoietic progenitors and their utility to study several aspects of hematopoietic stem cell biology are discussed here."
Springer
2008-03
Artículo
Andrade-Zaldívar, H., Santos, L. & De León Rodríguez, A. Cytotechnology (2008) 56: 151. https://doi.org/10.1007/s10616-008-9144-1
CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA
Versión aceptada
acceptedVersion - Versión aceptada
Aparece en las colecciones: Publicaciones Científicas Biología Molecular

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