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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1643| Cytotoxicity induced by carbon nanotubes in experimental malignant glioma | |
| SAMUEL ROMANO FEINHOLZ EMILIO MUÑOZ SANDOVAL ROXANA MAGAÑA MALDONADO EDGAR RANGEL LOPEZ ALBERTO GONZALEZ AGUILAR julio Sotelo VERONICA PEREZ DE LA CRUZ Benjamin Pineda | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.2147/IJN.S139004 | |
| Carbon nanotubes Glioblastoma therapy Temozolomide Malignant glioma | |
| "Despite multiple advances in the diagnosis of brain tumors, there is no effective treatment for glioblastoma. Multiwalled carbon nanotubes (MWCNTs), which were previously used as a diagnostic and drug delivery tool, have now been explored as a possible therapy against neoplasms. However, although the toxicity profile of nanotubes is dependent on the physicochemical characteristics of specific particles, there are no studies exploring how the effectivity of the carbon nanotubes (CNTs) is affected by different methods of production. In this study, we characterize the structure and biocompatibility of four different types of MWCNTs in rat astrocytes and in RG2 glioma cells as well as the induction of cell lysis and possible additive effect of the combination of MWCNTs with temozolomide. We used undoped MWCNTs (labeled simply as MWCNTs) and nitrogen-doped MWCNTs (labeled as N-MWCNTs). The average diameter of both pristine MWCNTs and pristine N-MWCNTs was ~22 and ~35 nm, respectively. In vitro and in vivo results suggested that these CNTs can be used as adjuvant therapy along with the standard treatment to increase the survival of rats implanted with malignant glioma." | |
| Dove Press Ltd | |
| 2017 | |
| Artículo | |
| Romano-Feinholz, S., Salazar-Ramiro, A., Muñoz-Sandoval, E., Magaña-Maldonado, R., Hernández Pedro, N., Rangel López, E., … Pineda, B. (2017). Cytotoxicity induced by carbon nanotubes in experimental malignant glioma. International Journal of Nanomedicine, 12, 6005–6026. http://doi.org/10.2147/IJN.S139004 | |
| CIENCIAS TECNOLÓGICAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Nanociencias y Materiales |
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| IntJNanomed12(2017)6005.pdf | 10.92 MB | Adobe PDF | Visualizar/Abrir |