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Dynamic infrared thermography of nanoheaters embedded in skin-equivalent phantoms
KARLA ALEJANDRA LOPEZ VARELA
NICOLAS CAYETANO CASTRO
ELEAZAR SAMUEL KOLOSOVAS MACHUCA
Francisco Gonzalez
Fernando Sebastián Chiwo
JOSE LUIS RODRIGUEZ LOPEZ
Acceso Abierto
Atribución-NoComercial-SinDerivadas
https://doi.org/10.1155/2018/3847348
Gold nanoparticles
In-vivo
Photothermal therapy
Drug-delivery
Hepes buffer
Nanomaterials
Nanostars
Cancer
Seed
Nanocrystals
"Nanoheaters are promising tools for localized photothermal therapy (PTT) of malignant cells. The anisotropic AuNPs present tunable surface plasmon resonances (SPR) with ideal NIR optical response to be applied as theranostic agents. To this purpose, nanoparticles with branches are suitable because of the electromagnetic field concentrated at their vertices. We standardized a protocol to synthesize multibranched gold nanoparticles (MB-AuNPs) by the seed-growth method and found a size-seed dependence tunability on the hierarchy of branching. Once the optical response is evaluated, we tested the temporal stability as nanoheaters of the MB-AuNPs immersed in skin-equivalent phantoms by dynamic infrared thermography (DIRT). The most suited sample presents a concentration of 5.2 x 10(8) MB-AuNPs/mL showing good thermal stability with Delta T = 4.5 degrees C, during 3 cycles of 10 min at 785 nm laser irradiation with power of 0.15 W. According to these results, the MB-AuNPs are suitable nanoheaters to be tested for PTT in more complex models."
Hindawi Publishing Corporation
2018
Artículo
K. A. López-Varela, N. Cayetano-Castro, E. S. Kolosovas-Machuca, F. J. González, F. S. Chiwo, and J. L. Rodríguez-López, “Dynamic Infrared Thermography of Nanoheaters Embedded in Skin-Equivalent Phantoms,” Journal of Nanomaterials, vol. 2018, Article ID 3847348, 8 pages, 2018. https://doi.org/10.1155/2018/3847348.
CIENCIAS TECNOLÓGICAS
Versión publicada
publishedVersion - Versión publicada
Aparece en las colecciones: Publicaciones Científicas Nanociencias y Materiales

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