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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1929| Cholinergic signaling plasticity maintains viscerosensory responses during Aspiculuris tetraptera infection in mice small intestine | |
| Egina Criseida Villalobos Hernández Carlos Barajas López ELIZABETH AURELIA MARTINEZ SALAZAR ROBERTO CARLOS SALGADO DELGADO Marcela Miranda Morales | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1016/j.autneu.2017.06.001 | |
| Mechanosensitive response Afferent multifiber recordings Gastrointestinal sensory fibers Acetylcholine responses Aspiculuris tetraptera | |
| "Intestinal parasites alter gastrointestinal (GI) functions like the cholinergic function. Aspiculuris tetraptera is a pinworm frequently observed in laboratory facilities, which infests the mice cecum and proximal colon. However, little is known about the impact of this infection on the GI sensitivity. Here, we investigated possible changes in spontaneous mesenteric nerve activity and on the mechanosensitivity function of worm-free regions of naturally infected mice with A. tetraptera. Infection increased the basal firing of mesenteric afferent nerves in jejunum. Our findings indicate that nicotinic but not muscarinic receptors, similarly affect spontaneous nerve firing in control and infected animals; these axons are mainly vagal. No difference between groups was observed on spontaneous activity after nicotinic receptor inhibition. However, and contrary to the control group, during infection, the muscarinic signaling was shown to be elevated during mechanosensory experiments. In conclusion, we showed for the first time that alterations induced by infection of the basal afferent activity were independent of the cholinergic function but changes in mechanosensitivity were mediated by muscarinic, but not nicotinic, receptors and specifically by high threshold nerve fibers (activated above 20 mm Hg), known to play a role in nociception. These plastic changes within the muscarinic signaling would function as a compensatory mechanism to maintain a full mechanosensory response and the excitability of nociceptors during infection. These changes indicate that pinworm colonic infection can target other tissues away from the colon." | |
| Elsevier | |
| 2017 | |
| Artículo | |
| Egina C. Villalobos-Hernández, Carlos Barajas-López, Elizabeth A. Martínez-Salazar, Roberto C. Salgado-Delgado, Marcela Miranda-Morales, Cholinergic signaling plasticity maintains viscerosensory responses during Aspiculuris tetraptera infection in mice small intestine, Autonomic Neuroscience, Volume 206, 2017, Pages 8-18. | |
| NEUROCIENCIAS | |
| Versión aceptada | |
| acceptedVersion - Versión aceptada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| AutonomicNeuroscience206(2017)8.pdf | 950.47 kB | Adobe PDF | Visualizar/Abrir |