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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1944| Multistability in a prion replication interconnected cell reaction network | |
| JOSE MARTIN MENDEZ GONZALEZ Irene Otero_Muras | |
| En Embargo | |
| 31-12-2021 | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1016/j.ifacol.2018.09.043 | |
| Bistability Prion kinetics Interconnected cells Biochemical Reaction Network | |
| "Aggregation of misfolded proteins has been implicated in a number of neurodegenerative disorders including prion disease. In spite of intensive research, the detailed mechanisms of protein misfolding leading to protein aggregation remain unsolved. Here, we explore the capacity for bistability of several classes of mechanisms proposed in the literature and compatible with protein aggregation kinetic data sets (it has been shown that bistability explains thresholds phenomena observed in protein aggregation in vitro and in vivo). Using a novel method for bistability detection we find a plausible scenario for which the so called subsequent monomer addition model leads to bistability." | |
| International Federation of Automatic Control | |
| 2018 | |
| Artículo | |
| J.M. Méndez-González, Irene Otero-Muras, Multistability in a prion replication interconnected cell reaction network??First author acknowledge the financial support from Red de Proteínas, Priones y Enfermedades Neurodegenerativas (PRyEND) http://www.pryend.org/ IOM Acknowledges funding from the Spanish MINECO (and the European Regional Development Fund) project SYNBIOFACTORY (grant number DPI2014-55276-C5-2-R)., IFAC-PapersOnLine, Volume 51, Issue 19, 2018, Pages 62-63. | |
| MATEMÁTICAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Control y Sistemas Dinámicos |