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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1957| Adhesins in Candida glabrata | |
| Bea Timmermans Alejandro de las Peñas Nava Irene Beatriz Castaño Navarro Patrick Van Dijck | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/jof4020060 | |
| Candida glabrata Adhesin Adhesion Biofilm | |
| "The human fungal pathogen Candida glabrata is causing more and more problems in hospitals, as this species shows an intrinsic antifungal drug resistance or rapidly becomes resistant when challenged with antifungals. C. glabrata only grows in the yeast form, so it is lacking a yeast-to-hyphae switch, which is one of the main virulence factors of C. albicans. An important virulence factor of C. glabrata is its capacity to strongly adhere to many different substrates. To achieve this, C. glabrata expresses a large number of adhesin-encoding genes and genome comparisons with closely related species, including the non-pathogenic S. cerevisiae, which revealed a correlation between the number of adhesin-encoding genes and pathogenicity. The adhesins are involved in the first steps during an infection; they are the first point of contact with the host. For several of these adhesins, their importance in adherence to different substrates and subsequent biofilm formation was demonstrated in vitro or in vivo. In this review, we provide an overview of the role of C. glabrata adhesins during adhesion and biofilm formation both, under in vitro and in vivo conditions." | |
| MDPI AG | |
| 2018 | |
| Artículo | |
| Timmermans, B.; De Las Peñas, A.; Castaño, I.; Van Dijck, P. Adhesins in Candida glabrata. J. Fungi 2018, 4, 60. | |
| MICROBIOLOGÍA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| JFungi4(2018)60.pdf | 1.73 MB | Adobe PDF | Visualizar/Abrir |