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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1958| Candida glabrata’s genome plasticity confers a unique pattern of expressed cell wall proteins | |
| EUNICE LOPEZ FUENTES Ma. Guadalupe Gutiérrez Escobedo Bea Timmermans Patrick Van Dijck Alejandro de las Peñas Nava Irene Beatriz Castaño Navarro | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/jof4020067 | |
| Candida glabrata Cell wall proteins Adherence Virulence Fluconazole resistance Genome plasticity Subtelomeric silencing Clinical isolates | |
| "Candida glabrata is the second most common cause of candidemia, and its ability to adhere to different host cell types, to microorganisms, and to medical devices are important virulence factors. Here, we consider three characteristics that confer extraordinary advantages to C. glabrata within the host. (1) C. glabrata has a large number of genes encoding for adhesins most of which are localized at subtelomeric regions. The number and sequence of these genes varies substantially depending on the strain, indicating that C. glabrata can tolerate high genomic plasticity; (2) The largest family of CWPs (cell wall proteins) is the EPA (epithelial adhesin) family of adhesins. Epa1 is the major adhesin and mediates adherence to epithelial, endothelial and immune cells. Several layers of regulation like subtelomeric silencing, cis-acting regulatory regions, activators, nutritional signaling, and stress conditions tightly regulate the expression of many adhesin-encoding genes in C. glabrata, while many others are not expressed. Importantly, there is a connection between acquired resistance to xenobiotics and increased adherence; (3) Other subfamilies of adhesins mediate adherence to Candida albicans, allowing C. glabrata to efficiently invade the oral epithelium and form robust biofilms. It is noteworthy that every C. glabrata strain analyzed presents a unique pattern of CWPs at the cell surface." | |
| MDPI AG | |
| 2018 | |
| Artículo | |
| López-Fuentes, E.; Gutiérrez-Escobedo, G.; Timmermans, B.; Van Dijck, P.; De Las Peñas, A.; Castaño, I. Candida glabrata’s Genome Plasticity Confers a Unique Pattern of Expressed Cell Wall Proteins. J. Fungi 2018, 4, 67. | |
| MICROBIOLOGÍA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| JFungi4(2018)67.pdf | 1.25 MB | Adobe PDF | Visualizar/Abrir |