Por favor, use este identificador para citar o enlazar este ítem:
http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1968| Evaluation of vascular tone and cardiac contractility in response to silver nanoparticles, using Langendorff rat heart preparation | |
| MANUEL ALEJANDRO RAMIREZ LEE PEDRO PABLO MARTINEZ CUEVAS HECTOR ROSAS HERNANDEZ Cuauhtémoc Oros Ovalle MARIELA BRAVO SANCHEZ Gabriel Alejandro Martínez Castañón María del Carmen González Castillo | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1016/j.nano.2017.01.017 | |
| Silver nanoparticles Coronary vascular tone Myocardial contractility Nitric oxide Oxidative stress | |
| "Silver nanoparticles (AgNPs) have been widely used because of their antimicrobial properties. However, several reports suggest that AgNPs exposure promote cardiac effects that involve nitric oxide (NO) and oxidative stress (OS). Nevertheless, there are no studies related to AgNPs-induced effects in cardiac physiology. The aim of this study was to evaluate the AgNPs direct actions on coronary vascular tone and cardiac contractility using Langendorff rat heart preparation. Low concentrations of AgNPs (0.1 and 1 ?g/mL) increased NO derived from inducible NO-synthase (iNOS), without modifying cardiac parameters. Meanwhile, high concentrations (10 and 100 ?g/mL) promoted a sustained vasoconstriction and increased cardiac contractility related to OS, leading to rhabdomyolysis. Furthermore, AgNPs were internalized in the cardiac muscle, hindering classic actions induced by phenylephrine (Phe) and acetylcholine (ACh). These data suggest that AgNPs affect cardiac physiology in function of the concentration and in part of the NO generation, NOS expression and OS." | |
| Elsevier | |
| 2017 | |
| Artículo | |
| Alejandro Ramirez-Lee Manuel, Pedro Pablo Martinez-Cuevas, Hector Rosas-Hernandez, Cuauhtémoc Oros-Ovalle, Mariela Bravo-Sanchez, Gabriel Alejandro Martinez-Castañon, Carmen Gonzalez, Evaluation of vascular tone and cardiac contractility in response to silver nanoparticles, using Langendorff rat heart preparation, Nanomedicine: Nanotechnology, Biology and Medicine, Volume 13, Issue 4, 2017, Pages 1507-1518. | |
| CIENCIAS TECNOLÓGICAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Nanociencias y Materiales |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Nanomedicine13(2017)1507.pdf | 1.43 MB | Adobe PDF | Visualizar/Abrir |