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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/2093| Anthelmintic effect of Psidium guajava and Tagetes erecta on wild-type and Levamisole-resistant Caenorhabditis elegans strains | |
| DENIA MARIA PIÑA VAZQUEZ ZYANYA MAYORAL PEÑA MARICELA GOMEZ SANCHEZ Luis Antonio Salazar Olivo FAUSTO ARELLANO CARBAJAL | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1016/j.jep.2017.03.004 | |
| Anthelmintic Psidium guajava Tagetes erecta Caenorhabditis elegans Levamisole-resistance | |
| "Ethnopharmacological relevance Psidium guajava and Tagetes erecta have been used traditionally to treat gastrointestinal parasites, but their active metabolites and mechanisms of action remain largely unknown. Aim of the study To evaluate the anthelmintic potential of Psidium guajava and Tagetes erecta extracts on Levamisole-sensitive and Levamisole-resistant strains of the model nematode Caenorhabditis elegans. Materials and methods Aqueous extracts of Psidium guajava (PGE) and Tagetes erecta (TEE) were assayed on locomotion and egg-laying behaviors of the wild-type (N2) and Levamisole-resistant (CB193) strains of Caenorhabditis elegans. Results Both extracts paralyzed wild-type and Levamisole-resistant nematodes in a dose-dependent manner. In wild-type worms, TEE 25 mg/mL induced a 75% paralysis after 8 h of treatment and PGE 25 mg/mL induced a 100% paralysis after 4 h of treatment. PGE exerted a similar paralyzing effect on N2 wild-type and CB193 Levamisole-resistant worms, while TEE only partially paralyzed CB193 worms. TEE 25 mg/mL decreased N2 egg-laying by 65% with respect to the untreated control, while PGE did it by 40%. Conclusions Psidium guajava leaves and Tagetes erecta flower-heads possess hydrosoluble compounds that block the motility of Caenorhabditis elegans by a mechanism different to that of the anthelmintic drug Levamisole. Effects are also observable on oviposition, which was diminished in the wild-type worms. The strong anthelmintic effects in crude extracts of these plants warrants future work to identify their active compounds and to elucidate their molecular mechanisms of action." | |
| Elsevier | |
| 2017 | |
| Artículo | |
| Denia M. Piña-Vázquez, Zyanya Mayoral-Peña, Maricela Gómez-Sánchez, Luis A. Salazar-Olivo, Fausto Arellano-Carbajal, Anthelmintic effect of Psidium guajava and Tagetes erecta on wild-type and Levamisole-resistant Caenorhabditis elegans strains, Journal of Ethnopharmacology, Volume 202, 2017, Pages 92-96. | |
| FARMACOLOGÍA | |
| Versión aceptada | |
| acceptedVersion - Versión aceptada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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