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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/2384| Evolutionary variation in MADS-box dimerization affects floral development and protein stability | |
| MARIA JAZMIN ABRAHAM JUAREZ Amanda Schrager Lavelle Jarrett Man Clinton Whipple Pubudu Handakumbura Courtney Babbitt Madelaine Bartlett | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| "Shifting interactions between MADS-box transcription factors may have been critical in the emergence of the flower, and in floral diversification. However, how evolutionary variation in MADS-box interactions affects the development and evolution of floral form remains unknown. Interactions between B-class MADS-box proteins are variable across the grass family. Here, we test the functional consequences of this evolutionary variability using maize as an experimental system. We found that differential B-class dimerization was associated with subtle, quantitative differences in stamen shape. In contrast, differential dimerization resulted in large-scale changes to protein complex composition and downstream gene expression. Differential dimerization also affected B-class complex abundance, independent of RNA levels. Thus, differential dimerization may affect protein stability. This reveals an important consequence for evolutionary variability in MADS-box interactions, adding complexity to the evolution of developmental gene networks. Our results show that floral development is robust to molecular change, even coding change in a master regulator of development. This robustness may contribute to the evolvability of floral form." | |
| Cold Spring Harbor Laboratory | |
| 2020 | |
| Artículo | |
| María Jazmín Abraham-Juárez, Amanda Schrager-Lavelle, Jarrett Man, Clinton Whipple, Pubudu Handakumbura, Courtney Babbitt, Madelaine Bartlett, Evolutionary variation in MADS-box dimerization affects floral development and protein stability, bioRxiv 2020.03.09.984260; doi: https://doi.org/10.1101/2020.03.09.984260 | |
| BIOLOGÍA MOLECULAR | |
| Versión revisada | |
| submittedVersion - Versión revisada | |
| Aparece en las colecciones: | Publicaciones Científicas Biología Molecular |
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| bioRxiv(2020)984260.pdf | 5.48 MB | Adobe PDF | Visualizar/Abrir |