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http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/2596| Environmental Nanoparticles Reach Human Fetal Brains | |
| LILIAN OFELIA CALDERON GARCIDUEÑAS ANGEL AUGUSTO PEREZ CALATAYUD ANGELICA GONZALEZ MACIEL RAFAEL REYNOSO ROBLES Héctor Gabriel Silva Pereyra Andrea Ramos Morales RICARDO TORRES JARDON Candelario de Jesús Soberanes Cerino Raúl Carrillo Esper JESÚS CARLOS BRIONES GARDUÑO Yazmin del Socorro Conde Gutiérrez | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/biomedicines10020410 | |
| Environmental medicine Placental impairment Neurodevelopmental disorders Fetal brains Erythroblasts Preeclampsia Nanoparticles NPs extracellular vesicles Petrochemical pollution Villahermosa Tabasco | |
| "Anthropogenic ultrafine particulate matter (UFPM) and industrial and natural nanoparticles (NPs) are ubiquitous. Normal term, preeclamptic, and postconceptional weeks(PCW) 8–15 human placentas and brains from polluted Mexican cities were analyzed by TEM and energy-dispersive X-ray spectroscopy. We documented NPs in maternal erythrocytes, early syncytiotrophoblast, Hofbauer cells, and fetal endothelium (ECs). Fetal ECs exhibited caveolar NP activity and widespread erythroblast contact. Brain ECs displayed micropodial extensions reaching luminal NP-loaded erythroblasts. Neurons and primitive glia displayed nuclear, organelle, and cytoplasmic NPs in both singles and conglomerates. Nanoscale Fe, Ti, and Al alloys, Hg, Cu, Ca, Sn, and Si were detected in placentas and fetal brains. Preeclamptic fetal blood NP vesicles are prospective neonate UFPM exposure biomarkers. NPs are reaching brain tissues at the early developmental PCW 8–15 stage, and NPs in maternal and fetal placental tissue compartments strongly suggests the placental barrier is not limiting the access of environmental NPs. Erythroblasts are the main early NP carriers to fetal tissues. The passage of UFPM/NPs from mothers to fetuses is documented and fingerprinting placental single particle composition could be useful for postnatal risk assessments. Fetal brain combustion and industrial NPs raise medical concerns about prenatal and postnatal health, including neurological and neurodegenerative lifelong consequences." | |
| MDPI | |
| 2022 | |
| Artículo | |
| Calderón-Garcidueñas, L.; Pérez-Calatayud, Á.A.; González-Maciel, A.; Reynoso-Robles, R.; Silva-Pereyra, H.G.; Ramos-Morales, A.; Torres-Jardón, R.; Soberanes-Cerino, C.d.J.; Carrillo-Esper, R.; Briones-Garduño, J.C.; Conde-Gutiérrez, Y.d.S. Environmental Nanoparticles Reach Human Fetal Brains. Biomedicines 2022, 10, 410. https://doi.org/10.3390/biomedicines10020410 | |
| BIOQUÍMICA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Nanociencias y Materiales |
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| Biomedicines10(2022)410.pdf | 51.32 MB | Adobe PDF | Visualizar/Abrir |