Por favor, use este identificador para citar o enlazar este ítem:
http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/2156| Mechanisms of fasting-mediated protection against renal injury and fibrosis development after ischemic acute kidney injury | |
| PEDRO ROJAS MORALES EDILIA TAPIA RODRIGUEZ JUAN CARLOS LEON CONTRERAS SUSANA GONZALEZ REYES ANGELICA SARAI JIMENEZ OSORIO DANIELA JOYCE TRUJILLO SILVA NATALIA ISMENE PAVON MARTINEZ JESSICA GRANADOS PINEDA ROGELIO ENRIQUE HERNANDEZ PANDO LAURA GABRIELA SANCHEZ LOZADA HORACIO OSORIO ALONSO JOSE PEDRAZA CHAVERRI | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/biom9090404 | |
| Fasting Fibrosis Mitochondrial dysfunction Oxidative stress Inflammation ER stress Ischemia-reperfusion injury | |
| "Ischemia-reperfusion injury of the kidney may lead to renal fibrosis through a combination of several mechanisms. We recently demonstrated that fasting protects the rat kidney against oxidative stress and mitochondrial dysfunction in early acute kidney injury, and also against fibrosis development. Here we show that preoperative fasting preserves redox status and mitochondrial homeostasis at the chronic phase of damage after severe ischemia. Also, the protective effect of fasting coincides with the suppression of inflammation and endoplasmic reticulum stress, as well as the down-regulation of the mechanistic target of rapamycin (mTOR) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways in the fibrotic kidney. Our results demonstrate that fasting targets multiple pathophysiological mechanisms to prevent renal fibrosis and damage that results after renal ischemia-reperfusion injury." | |
| MDPI AG | |
| 2019 | |
| Artículo | |
| Rojas-Morales, P.; Tapia, E.; León-Contreras, J.C.; González-Reyes, S.; Jiménez-Osorio, A.S.; Trujillo, J.; Pavón, N.; Granados-Pineda, J.; Hernández-Pando, R.; Sánchez-Lozada, L.G.; Osorio-Alonso, H.; Pedraza-Chaverri, J. Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury. Biomolecules 2019, 9, 404. | |
| BIOLOGÍA VEGETAL (BOTÁNICA) | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Ciencias Ambientales |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Biomolecules9(2019)404.pdf | 6.12 MB | Adobe PDF | Visualizar/Abrir |