Por favor, use este identificador para citar o enlazar este ítem:
http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/2550| Antilymphoma Effect of Incomptine A: In Vivo, In Silico, and Toxicological Studies | |
| Fernando Calzada FRANCISCO ELIHU BAUTISTA REDONDA SERGIO NEMORIO HIDALGO FIGUEROA NORMAND GARCIA HERNANDEZ REYNA ELIZABETH BARBOSA CABRERA Claudia Velázquez ROSA MARIA ORDOÑEZ RAZO Angel Giovanni Arietta García | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/molecules26216646 | |
| Incomptine A Antilymphoma activity Molecular docking Acute toxicity Brine shrimp lethality Cancer Non-Hodgkin lymphoma | |
| "Incomptine A (IA) is a sesquiterpene lactone isolated from Decachaeta incompta that induces apoptosis, reactive oxygen species production, and a differential protein expression on the U-937 (diffuse histiocytic lymphoma) cell line. In this work, the antitumor potential of IA was investigated on Balb/c mice inoculated with U-937 cells and through the brine shrimp lethality (BSL) test. Furthermore, IA was subjected to molecular docking study using as targets proteins associated with processes of cancer as apoptosis, oxidative stress, and glycolytic metabolism. In addition to determining the potential toxicity of IA in human, its acute toxicity was performed in mice. Results reveals that IA showed high antilymphoma activity and BSL with an EC50 of 2.4 mg/kg and LC50 16.7 µg/mL, respectively. The molecular docking study revealed that IA has strong interaction on all targets used. In the acute oral toxicity, IA had a LD50 of 149 mg/kg. The results showed that the activities of IA including antilymphoma activity, BSL, acute toxicity, and in silico interactions were close to the methotrexate, an anticancer drug used as positive control. These findings suggest that IA may serve as a candidate for the development of a new drug to combat lymphoma." | |
| MDPI | |
| 2021 | |
| Artículo | |
| Calzada, F.; Bautista, E.; Hidalgo-Figueroa, S.; García-Hernández, N.; Barbosa, E.; Velázquez, C.; Ordoñez-Razo, R.M.; Arietta-García, A.G. Antilymphoma Effect of Incomptine A: In Vivo, In Silico, and Toxicological Studies. Molecules 2021, 26, 6646. https://doi.org/10.3390/molecules26216646 | |
| BIOLOGÍA MOLECULAR | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Publicaciones Científicas Ciencias Ambientales |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Molecules26(2021)6646.pdf | 3.22 MB | Adobe PDF | Visualizar/Abrir |